Kisspeptin-10 10mg

Buy Kisspeptin-10 Peptide for sale in the UK from Archeus Karma Bio, a trusted supplier of high-quality research-grade peptides. Kisspeptin-10 (also known as KP-10 or metastin 45-54) is a decapeptide encoded by the KISS1 gene and acts as the master upstream regulator of the reproductive hormone axis. It binds the KISS1R receptor (GPR54) in the hypothalamus and triggers the pulsatile release of gonadotropin-releasing hormone, which in turn drives luteinising hormone and follicle-stimulating hormone signalling. Because it sits above the entire hypothalamic-pituitary-gonadal cascade, Kisspeptin-10 has become a central compound in reproductive endocrinology, fertility and behavioural neuroscience research. Each batch from Archeus Karma Bio is lab-tested and verified for ≥99% purity, ensuring reliability and reproducibility in scientific research.

Key Features of Kisspeptin-10 Peptide for Sale

• Vial Size: 10mg per vial.
• Ultra-Pure Quality: Verified ≥99% purity by HPLC and Mass Spectrometry.
  Form: Lyophilized (freeze-dried) powder, intended strictly for laboratory research.
• Storage Instructions: Store between 2°C to 8°C (36 to 46°F), protected from light and moisture. After reconstitution, refrigerate and avoid multiple freeze-thaw cycles.
• Sequence: H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (YNWNSFGLRF-NH2).
• Molecular Formula: C(63)H(83)N(17)O(14); molecular weight approximately 1302.44 Da.
• CAS Number: 374675-21-5.
• Mechanism: Potent agonist at the KISS1R (GPR54) receptor, stimulating GnRH release and downstream LH and FSH secretion.

Scientific Overview: Mechanism & Research Applications

Mechanism of Action:

Kisspeptin-10 is the shortest biologically active fragment of the KISS1 gene product. It acts on KISS1R expressing neurons in the arcuate nucleus and preoptic area of the hypothalamus, the same neurons that generate the GnRH pulse. Activation of KISS1R signals through the Gq/11 and phospholipase C pathway, depolarising the neuron and producing GnRH release.

Because Kisspeptin sits one step above GnRH, it offers researchers a way to probe the reproductive axis at its origin rather than downstream, which is why it has largely replaced direct GnRH challenge in a number of experimental models.

Key Research Findings Include:

• Reproductive Axis Regulation: Triggers GnRH pulse generation and downstream LH and FSH release in experimental models.
• Fertility Research: Investigated as a trigger in assisted reproduction protocols and as a probe of hypothalamic function.
• Puberty and Development: Loss of function in KISS1R is associated with failure of pubertal onset, establishing the pathway as essential.
• Behavioural Neuroscience: Studied for its influence on limbic and paralimbic brain activity relating to arousal and bonding.
• Metabolic Interaction: Examined for the link between energy availability, leptin signalling and reproductive competence.